SINTESIS DAN IDENTIFIKASI STRUKTUR SENYAWA 3-(3,5-DINITROBENZOIL)-1-FENILTIOUREA SEBAGAI KANDIDAT ANTIKANKER

Authors

  • Susanti Susanti Universitas Perjuangan Tasikmalaya
  • Ruswanto Ruswanto STIKes Bakti Tunas Husada
  • Muharam Priatna STIKes Bakti Tunas Husada Tasikmalaya

DOI:

https://doi.org/10.36423/pharmacoscript.v1i2.102

Abstract

Thiourea derivatives are known to be potential anticancer agents. 3-(3,5-dinitrobenzoyl)-1-phenylthiourea as a thiourea derivatives has been synthesized through acylation between 3,5-dinitrobenzoyl chloride and 1-phenylthiourea in tetrahydrofuran with triethylamine ascatalyst through reflux process with stirring for 6 hours. The percentage of yield was13,86%. The purity of the product was shown by the single spot on the TLC and narrowrange of melting point. The structure identification results with UV spectrophotometry, IRspectroscopy and 1HNMR spectroscopy showed that the structure of the product wasappropriate to the prediction.

References

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Published

2019-08-26

Issue

Vol. 1 No. 2 (2018): Pharmacoscript

Section

Articles

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