DESAIN DAN STUDI INTERAKSI SENYAWA KOMPLEKS COBALT (II)-(1-BENZOYL-3-METHYL THIOUREAS) DENGAN DNA SEBAGAI KANDIDAT ANTIKANKER

Authors

  • Ruswanto Ruswanto Universitas Bakti Tunas Husada Tasikmalaya (ID Scopus:57194336756)
  • Mardianingrum Richa Universitas Perjuangan Tasikmalaya
  • Naser Fahmi Muhamad Universitas Bakti Tunas Husada

DOI:

https://doi.org/10.36423/pharmacoscript.v6i2.1264

Keywords:

Cobalt(II), DNA Dodecamer, docking, tiourea

Abstract

Kompleks logam Cobalt (II) dengan ligan turunan tiourea telah banyak diteliti dan dipelajari dalam pengembangan obat anti kanker. Tujuan penelitian adalah untuk menemukan kandidat antikanker yang lebih poten dari senyawa Cobalt (II)-tiourea dengan cara mempelajari interaksi pada DNA Dodecamer. Metode yang digunakan adalah simulasi docking dan prediksi farmakokinetik dan toksisitas. Dua senyawa Cobalt (II)-tiourea yaitu senyawa Bis-[3-methyl-1-(naphthalene-2-carbonyl)thiourea] Cobalt (III) dan Bis-[1-(4-heptylbenzoyl)-3-methylthiourea] Cobalt (III) yang diprediksi sebagai kandidat antikanker melalui interaksi dengan DNA Dodecamer.

References

Ahmed M., Lei, Ali M, Imran et al. 2019. Synthesis, characterization and anticancer activity of isonicotinylhydrazide metal complexes, J. Chem. Soc. Pak. Vol. 41(1). pp. 113-121.

Bielenica, A., Stefanska, J., Stepien, K., Napiorkowska, A., Augustynowicz-Kopec, E., Sanna, G., Madeddu, S., Boi, S., Giliberti, G., Wrzosek, M., & Struga, M. (2015). Synthesis, cytotoxicity and antimicrobial activity of thiourea derivatives incorporating 3-(trifluoromethyl)phenyl moiety. European Journal of Medicinal Chemistry, 101, 111–125. https://doi.org/10.1016/j.ejmech.2015.06.027

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Published

2023-09-01

Issue

Vol. 6 No. 2 (2023): Pharmacoscript

Section

Articles

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Copyright (c) 2023 Ruswanto, Mardianingrum Richa, Naser Fahmi Muhamad

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