• Kamri Andi Maulana Universitas Muslim Indonesia
  • Asmaliani Ira Universitas Muslim Indonesia



Education, Adherence, Knowledge, Tuberculosis, Family Environment


Compliance with medication for tuberculosis patients is one of the determinants of the success of therapy in addition to the effectiveness of antibiotics. The aim of this study is to identify the factors that influence the success of a therapy, in the long-term use of antibiotics for tuberculosis. We use questionnaires that we have created and validated in interviews and can be used to directly measure the level of compliance with the therapy experienced by the patient. This research method is an observational study with cross-sectional design and retrospective data collection. Respondents were patients with tuberculosis, both new and recurrent. The study sample consisted of 30 respondents with sequential sampling selection and the basis for patient interviews. The analysis used is a Chi-square binary between a variable in the history of tuberculosis with a long diagnosis during therapy that shows a relationship between education and family involvement in helping treatment especially in male patients with a P value <0,05. Multivariate analysis showed that men who never completed education even though they were still in a productive age had a low level of compliance. The results of the interviews showed that patients who obeyed the drug only reached 30% with scores reaching a score of 8. This is due to the large amount of medication taken, so the risk of success of therapy is very large. This research shows that the level of education, information, and family environment can support patient medication compliance. In addition, the more the amount of medication taken, the lower the patient's compliance.


Benzekri, N. A., Sambou, J. F., Tamba, I. T., Diatta, J. P., Sall, I., Cisse, O., Thiam, M., Bassene, G., Badji, N. M., Faye, K., Sall, F., Malomar, J. J., Seydi, M., & Gottlieb, G. S. (2019). Nutrition support for HIV-TB co-infected adults in Senegal, West Africa: A randomized pilot implementation study. PloS One, 14(7), e0219118.

Dayer LE, Shilling R, Van Valkenburg M, et al. 2017. Assessing the medication adherence app market place from the health professional and consumer vantage points. JMIR M health U health. 5(4):e45.

Frijters, E. M., Hermans, L. E., Wensing, A. M. J., Devillé, W. L. J. M., Tempelman, H. A., & De Wit, J. B. F. (2020). Risk factors for loss to follow-up from antiretroviral therapy programmes in low-income and middle-income countries. AIDS (London, England), 34(9), 1261–1288.

Gube AD, et al. 2017. Assesment of Anti-TB Drug Nonadherenceand associated Factor among TB Patient Attending TB Clinicsin Arba Minch Governmental Health Institutions, Southern Ethopia. Tuberculosis Research and Treatment. ID 3705812, 7;

Hanlon, P., Yeoman, L., Gibson, L., Esiovwa, R., Williamson, A. E., Mair, F. S., & Lowrie, R. (2018). A systematic review of interventions by healthcare professionals to improve management of non-communicable diseases and communicable diseases requiring long-term care in adults who are homeless. BMJ Open, 8(4), e020161.

Haramiova, Z., Stasko, M., Hulin, M., Tesar, T., Kuzelova, M., & Morisky, D. M. (2017). The effectiveness of daily SMS reminders in pharmaceutical care of older adults on improving patients’ adherence to antihypertensive medication (SPPA): study protocol for a randomized controlled trial. Trials, 18(1), 334.

Htun, Y. M., Khaing, T. M. M., Aung, N. M., Yin, Y., Myint, Z., Aung, S. T., Soonthornworasiri, N., Silachamroon, U., Kasetjaroen, Y., & Kaewkungwal, J. (2018). Delay in treatment initiation and treatment outcomes among adult patients with multidrug-resistant tuberculosis at Yangon Regional Tuberculosis Centre, Myanmar: A retrospective study. PloS One, 13(12), e0209932.

Karuniawati, H., Putra, O. N., & Wikantyasning, E. R. (2019). Impact of pharmacist counseling and leaflet on the adherence of pulmonary tuberculosis patients in lungs hospital in Indonesia. The Indian Journal of Tuberculosis, 66(3), 364–369.

Khachadourian, V., Truzyan, N., Harutyunyan, A., Petrosyan, V., Davtyan, H., Davtyan, K., van den Boom, M., & Thompson, M. E. (2020). People-centred care versus clinic-based DOT for continuation phase TB treatment in Armenia: a cluster randomized trial. BMC Pulmonary Medicine, 20(1), 105.

Morawsky K., et al. 2018. Association of a smartphone Application With Medication Adherence and Blood Pressure Control. JAMA interm Med. .doi:10.1001/jamainternmed.2018.0447.

Nunn, A. J., Phillips, P. P. J., Meredith, S. K., Chiang, C.-Y., Conradie, F., Dalai, D., van Deun, A., Dat, P.-T., Lan, N., Master, I., Mebrahtu, T., Meressa, D., Moodliar, R., Ngubane, N., Sanders, K., Squire, S. B., Torrea, G., Tsogt, B., & Rusen, I. D. (2019). A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis. The New England Journal of Medicine, 380(13), 1201–1213.

Puchalski Ritchie, L. M., van Lettow, M., Makwakwa, A., Kip, E. C., Straus, S. E., Kawonga, H., Hamid, J. S., Lebovic, G., Thorpe, K. E., Zwarenstein, M., Schull, M. J., Chan, A. K., Martiniuk, A., & van Schoor, V. (2020). Impact of a tuberculosis treatment adherence intervention versus usual care on treatment completion rates: results of a pragmatic cluster randomized controlled trial. Implementation Science : IS, 15(1), 107.

Ruan, Q.-L., Huang, X.-T., Yang, Q.-L., Liu, X.-F., Wu, J., Pan, K.-C., Shen, Y.-J., Cai, L.-M., Ling, Q., Jiang, T., Hong, J.-J., Wang, X.-D., Ma, C.-L., Peng, G.-Q., Wang, X.-Z., Mao, J.-C., Wu, T.-Z., Lin, M.-Y., Shao, L.-Y., & Zhang, W.-H. (2021). Efficacy and safety of weekly rifapentine and isoniazid for tuberculosis prevention in Chinese silicosis patients: a randomized controlled trial. Clinical Microbiology and Infection : The Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 27(4), 576–582.

Tola, H. H., Holakouie-Naieni, K., Tesfaye, E., Mansournia, M. A., & Yaseri, M. (2019). Prevalence of tuberculosis treatment non-adherence in Ethiopia: a systematic review and meta-analysis. The International Journal of Tuberculosis and Lung Disease : The Official Journal of the International Union against Tuberculosis and Lung Disease, 23(6), 741–749.

Tweed, C. D., Dawson, R., Burger, D. A., Conradie, A., Crook, A. M., Mendel, C. M., Conradie, F., Diacon, A. H., Ntinginya, N. E., Everitt, D. E., Haraka, F., Li, M., van Niekerk, C. H., Okwera, A., Rassool, M. S., Reither, K., Sebe, M. A., Staples, S., Variava, E., & Spigelman, M. (2019). Bedaquiline, moxifloxacin, pretomanid, and pyrazinamide during the first 8 weeks of treatment of patients with drug-susceptible or drug-resistant pulmonary tuberculosis: a multicentre, open-label, partially randomised, phase 2b trial. The Lancet. Respiratory Medicine, 7(12), 1048–1058.

Zegeye, A., Dessie, G., Wagnew, F., Gebrie, A., Islam, S. M. S., Tesfaye, B., & Kiross, D. (2019). Prevalence and determinants of anti-tuberculosis treatment non-adherence in Ethiopia: A systematic review and meta-analysis. PloS One, 14(1), e0210422.