AKTIVITAS HEPATOPROTEKTOR KOMBINASI RIMPANG TEMULAWAK (Curcuma xanthorriza Roxb.) DENGAN BUAH LADA HITAM (Piper nigri L.) PADA TIKUS WISTAR

Authors

  • Mochamad Herdi Nurzaman Universitas Perjuangan Tasikmalaya
  • Adila Awaludin Universitas Perjuangan Tasikmalaya
  • Salsabila Adlina Universitas Perjuangan Tasikmalaya

DOI:

https://doi.org/10.36423/pharmacoscript.v7i1.1589

Keywords:

Hepatoprotektor, Rifampisin, INH, Curcuma xanthorriza Roxb, Piper nigri L.

Abstract

Temulawak (Curcuma xanthorriza Roxb.) merupakan tanaman tradisional dengan kandungan utamanya adalah kurkuminoid yang berkhasiat hepatoprotektor. Penyerapan kurkuminoid yang buruk dapat ditingkatkan dengan piperin. Penelitian ini bertujuan untuk menguji efek hepatoprotektor kombinasi rimpang temulawak dengan buah lada hitam dalam bentuk kapsul yang terdiri dari temulawak/lada hitam (1520mg/40mg). Efek hepatoprotektor diuji pada tikus Wistar jantan yang diinduksi kerusakan hati dengan obat TB (isoniazid dan rifampisin). Dua dosis kombinasi yang diuji yaitu ekivalen dengan 2 Kapsul temulawak/lada hitam (TLH1) dan 3 kapsul temulawak/lada hitam (TLH2) masing-masing kombinasi simplisia uji tersebut. Hasil menunjukkan temulawak dan kombinasinya (TLH1 dan TLH2) mulai mencegah kerusakan hati pada pemberian hari ke-14 yang terlihat dari aktivitas ALT. Dilihat dari kadar albumin, temulawak maupun kombinasinya dapat memperbaiki kerusakan hati mulai hari ke-7 pemberian. Secara umum kombinasi lebih berpotensi mencegah dan mengobati kerusakan hati dibandingkan tanpa kombinasi.

References

Bishnoi, M., Chopra, K., Rongzhu, L., & Kulkarni, S. K. (2011). Protective effect of curcumin and its combination with piperine (bioavailability enhancer) against haloperidol-associated neurotoxicity: Cellular and neurochemical evidence. Neurotoxicity Research, 20(3), 215–225. https://doi.org/10.1007/s12640-010-9229-4

Devaraj, S., Ismail, S., Ramanathan, S., Marimuthu, S., & Fei, Y. M. (2010). Evaluation of the hepatoprotective activity of standardized ethanolic extract of Curcuma xanthorrhiza Roxb. Journal of Medicinal Plants Research, 4(23), 2512–2517. https://doi.org/10.5897/jmpr10.453

Khan, H., Ullah, H., & Nabavi, S. M. (2019). Mechanistic insights of hepatoprotective effects of curcumin: Therapeutic updates and future prospects. Food and Chemical Toxicology, 124, 182–191. https://doi.org/10.1016/j.fct.2018.12.002

Llano, S., Gómez, S., Londoño, J., & Restrepo, A. (2019). Antioxidant activity of curcuminoids. Physical Chemistry Chemical Physics, 21(7), 3752–3760. https://doi.org/10.1039/c8cp06708b

Pal, R., Vaiphei, K., Sikander, A., Singh, K., & Rana, S. V. (2006). Effect of garlic on isoniazid and rifampicin-induced hepatic injury in rats. World Journal of Gastroenterology, 12(4), 636–639. https://doi.org/10.3748/wjg.v12.i4.636

Shivarkar R, S. Bhise, M. G. (2021). Antituberculor activity of Curcuminoids isolated from Curcuma longa Rhizomes. 13(01), 5958. https://doi.org/10.5958/0975-4385.2021.00002.9

Sirisidthi, K., Kosai, P., Jiraungkoorskul, K., & Jiraungkoorskul, W. (2016). Antithrombotic activity of turmeric (Curcuma longa): A review. Indian Journal of Agricultural Research, 50(2), 101–106. https://doi.org/10.18805/ijare.v50i2.9586

Wiendarlina, I. Y., Rahminiwati, M., & Gumelar, F. T. (2019). AKTIFITAS HEPATOPROTEKTOR EKSTRAK AIR HERBA PEGAGAN DAUN KECIL (Centella asiatica L. Urb.) TERHADAP TIKUS PUTIH JANTAN Sprague Dawley L. YANG DIINDUKSI DENGAN PARASETAMOL. FITOFARMAKA: Jurnal Ilmiah Farmasi, 8(1), 12–22. https://doi.org/10.33751/jf.v8i1.1167

Yue, J., Peng, R., Chen, J., Liu, Y., & Dong, G. (2009). Effects of rifampin on CYP2E1-dependent hepatotoxicity of isoniazid in rats. Pharmacological Research, 59(2), 112–119. https://doi.org/10.1016/j.phrs.2008.10.006

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Published

2024-05-29

Issue

Vol. 7 No. 1 (2024): Pharmacoscript

Section

Articles

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Copyright (c) 2024 Mochamad Herdi Nurzaman, Adila Awaludin, Salsabila Adlina

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