AKTIVITAS HEPATOPROTEKTOR KOMBINASI RIMPANG TEMULAWAK (Curcuma xanthorriza Roxb.) DENGAN BUAH LADA HITAM (Piper nigri L.) PADA TIKUS WISTAR

Authors

  • Mochamad Herdi Nurzaman Universitas Perjuangan Tasikmalaya
  • Adila Awaludin Universitas Perjuangan Tasikmalaya
  • Salsabila Adlina Universitas Perjuangan Tasikmalaya

DOI:

https://doi.org/10.36423/pharmacoscript.v7i1.1589

Keywords:

Hepatoprotektor, Rifampisin, INH, Curcuma xanthorriza Roxb, Piper nigri L.

Abstract

Temulawak (Curcuma xanthorriza Roxb.) merupakan tanaman tradisional dengan kandungan utamanya adalah kurkuminoid yang berkhasiat hepatoprotektor. Penyerapan kurkuminoid yang buruk dapat ditingkatkan dengan piperin. Penelitian ini bertujuan untuk menguji efek hepatoprotektor kombinasi rimpang temulawak dengan buah lada hitam dalam bentuk kapsul yang terdiri dari temulawak/lada hitam (1520mg/40mg). Efek hepatoprotektor diuji pada tikus Wistar jantan yang diinduksi kerusakan hati dengan obat TB (isoniazid dan rifampisin). Dua dosis kombinasi yang diuji yaitu ekivalen dengan 2 Kapsul temulawak/lada hitam (TLH1) dan 3 kapsul temulawak/lada hitam (TLH2) masing-masing kombinasi simplisia uji tersebut. Hasil menunjukkan temulawak dan kombinasinya (TLH1 dan TLH2) mulai mencegah kerusakan hati pada pemberian hari ke-14 yang terlihat dari aktivitas ALT. Dilihat dari kadar albumin, temulawak maupun kombinasinya dapat memperbaiki kerusakan hati mulai hari ke-7 pemberian. Secara umum kombinasi lebih berpotensi mencegah dan mengobati kerusakan hati dibandingkan tanpa kombinasi.

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Published

2024-03-13

Issue

Vol. 7 No. 1 (2024): Pharmacoscript

Section

Articles

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Copyright (c) 2024 Mochamad Herdi Nurzaman, Adila Awaludin, Salsabila Adlina

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