OPTIMASI FORMULA SERUM NANOEMULSI EKSTRAK KULIT BUAH MAHKOTA DEWA DENGAN PENDEKATAN SIMPLEX LATTICE DESIGN

Authors

  • Rosdianto Rizzqi Septiprajaamalia Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Muhammadiyah Bandung
  • Imansari Mutiara Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Muhammadiyah Bandung
  • Setyaningrum Dwi Larasati Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Muhammadiyah Bandung
  • Azhari Azkya Nurliza Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Muhammadiyah Bandung
  • Mu'zizat Ridwan Program Studi Sarjana Farmasi, Fakultas Farmasi, Universitas Muhammadiyah Bandung

DOI:

https://doi.org/10.36423/pharmacoscript.v9i1.2499

Keywords:

Mahkota Dewa, Nanoemulsi, Serum, Simplex Lattice Design, Optimasi

Abstract

Kulit buah mahkota dewa (Phaleria macrocarpa) mengandung senyawa flavonoid dan fenolik yang berperan sebagai antioksidan alami. Potensi ini mendorong pengembangan sediaan topikal dalam bentuk serum nanoemulsi untuk aplikasi kosmetik anti-aging. Penelitian ini bertujuan untuk mengoptimasi formula serum nanoemulsi ekstrak kulit buah mahkota dewa menggunakan rancangan Simplex Lattice Design (SLD). Komponen utama formula nanoemulsi meliputi sunflower oil sebagai fase minyak, Cremophor RH 40 sebagai surfaktan dan PEG 400 sebagai ko-surfaktan. Parameter evaluasi yang dianalisis adalah ukuran droplet, Polydispersity Index (PDI) dan zeta potensial sebagai indikasi stabilitas sistem. Hasil optimasi menunjukkan bahwa formula optimum mampu menghasilkan ukuran droplet rata-rata 25,83 nm ± 0,83 nm dan indeks polidispersitas 0,48 ± 0,10 serta nilai zeta potensial -7,83 mV ± 1,00 mV. Penerapan rancangan SLD terbukti efektif dalam menentukan kombinasi komponen yang optimal sehingga diperoleh sediaan serum nanoemulsi yang stabil dan berpotensi dikembangkan sebagai produk kosmetik antioksidan berbasis bahan alam.

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Published

2026-02-28

Issue

Vol. 9 No. 1 (2026): Pharmacoscript

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Articles

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Copyright (c) 2026 Rosdianto Rizzqi Septiprajaamalia, Imansari Mutiara, Setyaningrum Dwi Larasati, Azhari Azkya Nurliza, Mu'zizat Ridwan

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