ANTIHYPERTENSIVE POTENTIAL OF Anredera cordifolia: A NARRATIVE REVIEW OF PRECLINICAL AND CLINICAL EVIDENCE
DOI:
https://doi.org/10.36423/pharmacoscript.v9i2.2954Keywords:
Anredera cordifolia, Antihypertensive activity, Blood pressure, Hypertension, PhytochemicalsAbstract
Hypertension is a condition that develops gradually but can suddenly lead to serious consequences, including death. The use of natural ingredients as adjunctive therapy continues to grow, including Anredera cordifolia, more commonly known as the binahong plant. Ethanol extracts of A. cordifolia leaves are known to contain vitexin (flavonoids), tannins, saponins, betalains, betanidin (alkaloids), phenols, terpenoids, and ursolic acid. A narrative review was conducted to identify relevant studies published in PubMed, Scopus, and Google Scholar databases between 2016 and 2026. The search terms related to “Anredera” AND “Hypertensive” found 625 articles. Following the screening of titles and abstracts and subsequent full-text assessment based on the predefined inclusion and exclusion criteria, 15 articles were considered eligible and included in the review. The articles consistently demonstrated that A. cordifolia leaves exhibit antihypertensive effects in vitro, ex vivo, in vivo, and through empirical use in humans. In humans, it lowers both systolic and diastolic blood pressure. These antihypertensive activities occur through several mechanisms, including inhibition of angiotensin-converting enzyme (ACE), vasodilatory effects via the nitric oxide (NO) pathway, inhibition of angiotensin type 1 receptors and adrenergic receptors, and as a (weak) diuretic. This presents an opportunity to develop traditional medicine as an adjunct to antihypertensive therapy. However, further clinical research is still needed to confirm its efficacy, safety, and optimal dosage for human use.
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